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Home Antibody All anti-TP53 antibodies

Anti-TP53 Antibody Y179

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA300470 Rabbit Monoclonal Antibody against TP53 (Clone Y179) 100ul $325 3-7 Days
LC400186 TP53 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(4)
IF(1)
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OriGene Data

ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Serine 6 of human p53 was used as immunogen. The antibody will detect p53 phosphorylation on Serine 6. Predicted to react with p53 beta and gamma isoform, based on sequence homology.
Clone NameY179 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1: 1,000-5,000; IHC: 1:250-500; ICC: 1:250-500; IP: 1: 100
Predicted MW Explanation 44 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification IgG fraction
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens tumor protein p53 (TP53), transcript variant 1
Alternative NameBCC7; LFS1; P53; TRP53
Database LinkNP_000537
Entrez Gene 7157 Human
Functionp53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair (1,2). The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers (3). p53 is frequently mutated or inactivated in about 60% of cancers (4,5).
Related PathwayStem cell - PluripotencyTranscription FactorsDruggable Genome MAPK signaling pathwayCell cyclep53 signaling pathwayApoptosisWnt signaling pathwayNeurotrophin signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


WB Image
Western blot - p53 (phospho S6) antibody [Y179]; All lanes : Anti-p53 (phospho S6) antibody [Y179] at 1/5000 dilution.Lane 1 : MCF7 cell lysate, non-treated.Lane 2 : MCF7 cell lysate, treated with Actinomycin D for 3 hours.Lane 3 : MCF7 cell lysate, treated with Actinomycin D for 6 hours.Lane 4 : MCF7 cell lysate, treated with Actinomycin D for 18 hours.Predicted band size : 44 kDa.Observed band size : 53 kDa .
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IHC Image
Immunohistochemistry (Paraffin-embedded sections) - p53 (phospho S6) antibody [Y179]; Immunohistochemical analysis of paraffin-embedded human urinary bladder carcinoma using TA300470 at 1/250 dilution.
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IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-p53 (phospho S6) antibody [Y179](TA300470); TA300470 showing positive staining in Lung adenocarcinoma tissue.
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IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-p53 (phospho S6) antibody [Y179](TA300470); TA300470 showing positive staining in Breast carcinoma tissue.
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IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-p53 (phospho S6) antibody [Y179](TA300470); TA300470 showing positive staining in Colonic adenocarcinoma tissue.
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IF Image
Immunocytochemistry/ Immunofluorescence - p53 (phospho S6) antibody [Y179]; Immunofluorescent analysis of A431 cells using TA300470 at 1/250 dilution.
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