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Anti-STAT6 Antibody YE361
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for STAT6 (NM_003153)
|A synthetic peptide corresponding to residues near C-terminus of human Stat-6 was used as immunogen. The antibody does not cross-react with other Stat family members.|
|WB, IHC, IF
||WB: 1:500; IHC: 1: 100-250; ICC: 1: 100; IP: 1:80
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens signal transducer and activator of transcription 6, interleukin-4 induced (STAT6), transcript variant 2|
|D12S1644; IL-4-STAT; STAT6B; STAT6C|
|Janus family tyrosine kinases (Jaks) and signal transducers and activators of transcription (STATs) are involved in mediating gene expression in response to cytokines and interferons. Jaks associate with cytokine receptors; upon ligand binding, Jaks phosphorylate the receptor. The phosphorylated receptors are bound by SH2-containing proteins, one class of which is the STATs. Activated STATs, then, translocate to the nucleus to mediate gene transcription (1,2). Stat-6 is tyrosine phosphorylated in response to cellular interaction with IL-3 and IL-4 (3,4). |
Jak-STAT signaling pathway
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Western blot analysis on NIH 3T3 cell lysate using anti-Stat-6, dilution 1:1,000
Immunohistochemical staining of paraffin-embedded human skin carcinoma using anti-Stat-6.
Immunofluorescent staining of HeLa cells using anti-Stat-6.