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 Home All anti-PXN antibodies

Anti-PXN Antibody Y113

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SKU Description Amount Price Availability*  
TA300443
  • Rabbit Monoclonal Antibody against PXN (Clone Y113)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401010) , 20ug
 100µl $325 3-7 Days
TA802519S
  • Purified GAPDH mouse monoclonal antibody (Loading control), clone 2D9
 30ul
$100
$50*		 In Stock
Add to Shopping Cart
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
WB(1)
IHC(1)
IF(1)
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Also for PXN (NM_002859)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in N-terminus of human Paxillin was used as immunogen. This antibody detects alpha, beta and gamma isoforms of Paxillin.
Clone NameY113 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:5,000-10,000; IHC: 1: 100; ICC: 1:250; IP: 1:200
Buffer50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

Reference Data

Target NameHomo sapiens paxillin (PXN), transcript variant 1
Alternative NameFLJ16691
Database LinkNP_002850
FunctionPaxillin is a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion) (1). Paxillin plays a significant role in integrin signaling and the tyrosine phosphorylation of paxillin is required for integrin-mediated cytoskeletal reorganization (2). Paxillin is phosphorylated by focal adhesion kinase (FAK) at Tyr118 (3). It has been found that phosphorylation of paxillin at both Tyr118 and Tyr31 is essential for MM1 cancer cell migration (4).
Related Pathway
EGFR1 Signaling Pathway
Focal Adhesion

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis on Hela cell lysate using anti-Paxilin (N-term), dilution 1:10,000.
IHC Image
Immunohistochemical analysis of paraffin-embedded breast carcinoma using anti-Paxillin (N-term).
IF Image
Immunofluorescent staining of HeLa cells using anti-Paxillin (N-term).

 

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