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Anti-RPS6KB1 Antibody E343
Also for RPS6KB1 (NM_003161)
|A synthetic peptide corresponding to residues in N-terminus of human p70 S6 kinase was used as immunogen. This antibody detects both alpha I and alpha II isoforms.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:5000 - 1:10000; IHC-P: Use at an assay dependent dilution; FC: 1:20; IP: 1:80
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for ICC.
|Homo sapiens ribosomal protein S6 kinase, 70kDa, polypeptide 1 (RPS6KB1), transcript variant 1|
|p70 S6KA; p70(S6K)-alpha; p70-alpha; p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A|
Entrez Gene 6198 Human
Entrez Gene 72508 Mouse
Entrez Gene 83840 Rat
|p70 S6 Kinase is a mitogen-activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression (1). p70 S6 kinase phosphorylates specifically ribosomal protein S6. Activation of p70 S6 kinase is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains (2). Activation occurs via phosphorylation at Ser411, Thr421 and Ser424 within the pseudosubstrate region (3, 4). Phosphorylation of Thr229 in the catalytic domain and Thr389 in the linker domain are most critical for kinase function (2). |
TGF Beta Signaling Pathway
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Western blot - P70 S6 Kinase antibody [E343]; Anti-S6K1 antibody [E343] at 1/10000 dilution + 293T cell lysate.Predicted band size : 59 kDa.Observed band size : 70 kDa .