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Home Antibody All anti-RPS6KB1 antibodies

Anti-RPS6KB1 Antibody E343

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300438
  • Rabbit Monoclonal Antibody against RPS6KB1 (Clone E343)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401097) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for RPS6KB1 (NM_003161)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in N-terminus of human p70 S6 kinase was used as immunogen. This antibody detects both alpha I and alpha II isoforms.
Clone NameE343 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:5000 - 1:10000; IHC-P: Use at an assay dependent dilution; FC: 1:20; IP: 1:80
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification IgG fraction
Note Is unsuitable for ICC.

Reference Data

Target NameHomo sapiens ribosomal protein S6 kinase, 70kDa, polypeptide 1 (RPS6KB1), transcript variant 1
Alternative Namep70 S6KA; p70(S6K)-alpha; p70-alpha; p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A
Database LinkNP_003152
Entrez Gene 6198 Human
Entrez Gene 72508 Mouse
Entrez Gene 83840 Rat
Functionp70 S6 Kinase is a mitogen-activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression (1). p70 S6 kinase phosphorylates specifically ribosomal protein S6. Activation of p70 S6 kinase is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains (2). Activation occurs via phosphorylation at Ser411, Thr421 and Ser424 within the pseudosubstrate region (3, 4). Phosphorylation of Thr229 in the catalytic domain and Thr389 in the linker domain are most critical for kinase function (2).
Related Pathway
TGF Beta Signaling Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - P70 S6 Kinase antibody [E343]; Anti-S6K1 antibody [E343] at 1/10000 dilution + 293T cell lysate.Predicted band size : 59 kDa.Observed band size : 70 kDa .

 

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