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OriGene Antibodies in recent publications
A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431. [anti-DDK]
Excitotoxicity Upregulates SARM1 Protein Expression and Promotes Wallerian-Like Degeneration of Retinal Ganglion Cells and Their Axons Invest. Ophthalmol. Vis. Sci., Apr 2013; 54: 2771 - 2780. [SARM1]
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX Nature 497, 122-126 doi:10.1038/nature12052 [anti-DDK]
Natriuretic Peptide Receptor-3 Gene (NPR3): Nonsynonymous Polymorphism Results in Significant Reduction in Protein Expression Because of Accelerated Degradation Circ Cardiovasc Genet, Apr 2013; 6: 201 - 210. [NPR3]
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 Home All anti-KRT18 antibodies

Anti-KRT18 Antibody E431-1

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Specifications Related Products Conjugation/Bulk FAQs
SKU Description Amount Price Availability*  
TA300412
  • Rabbit Monoclonal Antibody against KRT18 (Clone E431-1)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400083) , 20ug
 100µl $325 3-7 Days Add to Shopping Cart
WB(1)
IHC(1)
Gene NameHomo sapiens keratin 18 (KRT18), transcript variant 1
Synonyms:CYK18; K18
ImmunogenA synthetic peptide corresponding to residues of human Cytokeratin 18 was used as immunogen.
Buffer50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Clone NameE431-1 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1: 10,000; IHC: 1: 100-1:250; ICC: 1: 100; FC: 1:20
BackgroundKeratin polypeptides 8 and 18 (K8/18) are intermediate filament phosphoglycoproteins that are expressed preferentially in glandular epithelia. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells (1-3). Together with actin microfilaments and microtubules, keratin filaments make up the cytoskeletons of vertebrate eptithelial cells, forming alphahelical coiled-coil dimers which associate laterally and end to end to form 10-nm diameter filaments (4).
Related Pathway
EGFR1 Signaling Pathway

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WB Image
Western blot analysis on A431 cell lysate using anti-Keratin 18, dilution 1:10,000.
IHC Image
Immunohistochemical analysis of paraffin-embedded colon carcinoma using anti-Keratin 18.

 

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