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Anti-LBR Antibody E398L


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SKU Description Amount Price Availability*  
TA300408 Rabbit Monoclonal Antibody against LBR (Clone E398L) 100ul $325 In Stock
LC419408 LBR HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues of human Lamin B Receptor was used as immunogen.
Clone NameE398L IsotypeIgG
Species ReactivityRat, Human (Does not react with: Mouse) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsIP: 1:50; WB: 1:500; ICC/IF: 1:500; IHC-P: Use a concentration of 5 ug/ml
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens lamin B receptor (LBR), transcript variant 1
Alternative NameDHCR14B; LMN2R; PHA; TDRD18
Database LinkNP_002287
Entrez Gene 3930 Human
Entrez Gene 89789 Rat
FunctionLamins are nuclear membrane proteins that serve to maintain specific cellular functions, such as DNA replication and chromatin organization (1). Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures (2). The cleavage of lamins results in nuclear disregulation and cell death (3,4).
Related PathwayTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Lamin B Receptor antibody [E398L]; Anti-Lamin B Receptor antibody [E398L] at 1/500 dilution + Jurkat cell lysate.Predicted band size : 71 kDa.Observed band size : 67 kDa .
IHC image of TA300408 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6) for 20 mins. The section was then incubated with TA300408, 5ug/ml, for 15 mins at RT and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Immunocytochemistry/ Immunofluorescence - Lamin B Receptor antibody [E398L]; Ab32535, at a 1/500 dilution, staining Lamin B Receptor in HeLa cells by Immunofluorescence.


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