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Anti-LBR Antibody E398L
|A synthetic peptide corresponding to residues of human Lamin B Receptor was used as immunogen.|
|Rat, Human (Does not react with: Mouse)
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, IF
||IP: 1:50; WB: 1:500; ICC/IF: 1:500; IHC-P: Use a concentration of 5 ug/ml
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt.
|Homo sapiens lamin B receptor (LBR), transcript variant 1|
|DHCR14B; LMN2R; PHA; TDRD18|
Entrez Gene 3930 Human
Entrez Gene 89789 Rat
|Lamins are nuclear membrane proteins that serve to maintain specific cellular functions, such as DNA replication and chromatin organization (1). Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures (2). The cleavage of lamins results in nuclear disregulation and cell death (3,4). |
|TransmembraneDruggable Genome |
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Western blot - Lamin B Receptor antibody [E398L]; Anti-Lamin B Receptor antibody [E398L] at 1/500 dilution + Jurkat cell lysate.Predicted band size : 71 kDa.Observed band size : 67 kDa .
IHC image of TA300408 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6) for 20 mins. The section was then incubated with TA300408, 5ug/ml, for 15 mins at RT and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Immunocytochemistry/ Immunofluorescence - Lamin B Receptor antibody [E398L]; Ab32535, at a 1/500 dilution, staining Lamin B Receptor in HeLa cells by Immunofluorescence.