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Home Antibody All anti-BIRC3 antibodies

Anti-BIRC3 Antibody E40

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA300345 Rabbit Monoclonal Antibody against BIRC3 (Clone E40) 100ul $325 3-7 Days
LC420093 BIRC3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for BIRC3 (NM_001165)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues, before the breakpoint for translocation to form BIRC3-MALT1, of Human BIP3 was used as immunogen. The antibody does not cross-react with other IAP family members.
Clone NameE40 IsotypeIgG fraction
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application * Suggested DilutionsWB: 1:1000; IHC-P: Use at an assay dependent dilution; ICC: 1:100; IP: Use a concentration of 5 ug/ml
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification IgG fraction
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens baculoviral IAP repeat containing 3 (BIRC3), transcript variant 1
Alternative NameAIP1; API2; c-IAP2; CIAP2; HAIP1; HIAP1; MALT2; MIHC; RNF49
Database LinkNP_001156
Entrez Gene 330 Human
FunctioncIAP-2, also known as HIAP-1, is a member of the inhibitor of apoptosis (IAP) family of proteins. These proteins contain a BIR (baculovirus IAP repeat) domain near the amino-terminus (1). cIAP-2 is localized to the cytoplasm. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form a heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). This complex is thought to play a role in inhibition of apoptosis (2,3). cIAP-2 inhibits cytochrome c-induced activation of caspase-9, thereby preventing initiation of the caspase cascade and apoptosis (4).
Related PathwayDruggable Genome Ubiquitin mediated proteolysisApoptosisFocal adhesionNOD-like receptor signaling pathwayPathways in cancerSmall cell lung cancerMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

 

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