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Anti-TP53 Antibody E26
Also for TP53 (NM_000546)
|A synthetic peptide corresponding to residues following the transcription activation domain of human p53 was used as immunogen. The antibody should recognize human wild-type and mutant p53.|
||0.5~1.0 mg/ml (Lot Dependent)
|WB, IHC, IF
||WB: 1: 1,000; IHC: 1: 100; ICC: 1:50100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Does not react with Mouse, Rat
|Homo sapiens tumor protein p53 (TP53), transcript variant 1|
|BCC7; LFS1; P53; TRP53|
|p53 acts as both a tumor-suppressor and transcription factor that, upon activation by DNA damage and other cellular stress signals, leads to the transcription of genes triggering cell-cycle arrest, apoptosis, and DNA repair(1,2). The gene for the nuclear phosphoprotein p53 is the most commonly mutated gene yet identified in human cancers(3). p53 is frequently mutated or inactivated in about 60% of cancers (4,5).|
Delta-Notch Signaling Pathway
MAPK signaling pathway
Senescence and Autophagy
TGF Beta Signaling Pathway
Wnt Signaling Pathway
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Western blot - p53 antibody [E26]; Anti-p53 antibody [E26] at 1/1000 dilution + Jurkat cell lysate.Predicted band size : 44 kDa.Observed band size : 53 kDa .
Immunohistochemistry (Paraffin-embedded sections) - p53 antibody [E26]; Immunohistochemical analysis of paraffin embedded human breast carcinoma showing nuclear localization of p53 using TA300340 at 1/100 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p53 antibody [E26]; Immunohistochemical analysis of Human urinary bladder cancer tissue, staining p53 with TA300340 at 1/250 dilution. Staining was detected using DAB.
Immunocytochemistry/ Immunofluorescence - p53 antibody [E26]; Immunofluorescent staining of A431 cells using TA300340 at 1/100 dilution.