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Home Antibody All anti-CASP6 antibodies

Anti-CASP6 Antibody E180

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300316
  • Rabbit Monoclonal Antibody against CASP6 (Clone E180)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400490) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)
IF(1)
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Also for CASP6 (NM_001226)
cDNA Clone shRNA/siRNA Protein/Lysate Antibody Assay

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in C-terminus of human Caspase-6 was used as immunogen. The antibody should recognize both pro-form and p11 subunit.
Clone NameE180 IsotypeIgG
Species ReactivityHuman, Mouse ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:1000; IHC-P: Use at an assay dependent dilution; ICC/IF: 1:100; FC: 1:30
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens caspase 6, apoptosis-related cysteine peptidase (CASP6), transcript variant alpha
Alternative NameMCH2
Database LinkNP_001217
FunctionCaspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase-6 is a major apoptotic executioner (1,2). It exists as a pro-domain protein and is cleaved by caspase-3 into two active subunits, an 18 kDa and a 10 kDa subunit (3). Caspase-6 cleaves among many different intracellular proteins, nuclear lamins. Lamins play a significant role in maintaining the integrity of the cell membrane, and their cleavage results in subsequent cellular breakdown and death (4).
Related Pathway
Apoptosis
MAPK signaling pathway

* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Caspase 6 antibody [E180]; All lanes : Anti-Caspase 6 antibody [E180] at 1/1000 dilution.Lane 1 : Untreated Jurkat cell lysate. .Lane 2 : Jurkat cell lysate treated with Camptothecin. .Predicted band size : 34 kDa.Observed band size : 30 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Caspase 6 antibody [E180]; Ab32366, at a 1/50 dilution, staining Caspase 6 in paraffin embedded human lung adenocarcinoma tissue by Immunohistochemistry.
IF Image
Immunocytochemistry/ Immunofluorescence - Caspase 6 antibody [E180]; Ab32366, at a 1/100 dilution, staining Caspase 6 in Hela cells by Immunocytochemistry/Immunofluorescence.

 

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