Anti-ERBB2 Antibody, V2W

Also for ERBB2 (NM_004448)

Gene Name	Homo sapiens v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2), transcript variant 1
Synonyms:	CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Immunogen	A synthetic peptide corresponding to C-terminal residues of human ErbB2 was used as immunogen.
Buffer	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Clone Name	V2W	Isotype	IgG
Species Reactivity	Human	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB	Suggested Dilutions	WB: 1:5,000
Background	ErbB2/HER2 is one of the four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinases (1). The kinase activity of ErbB2 can be activated without ligand if it is overexpressed, and by association with other ErbB proteins (2). Overexpression of ErbB2 is detected in almost 40% of human breast cancers (3). Binding of c-Cbl ubiquitin ligase to Tyr1112 of ErbB2 leads to poly-ubiquitination of ErbB2 and enhances its degradation (4). ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas.
Related Pathway	Adherens junction Focal Adhesion

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WB Image

Western blot analysis on SKBR3 cell lysate using anti-ErbB2/HER2, dilution 1:5,000.

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Anti-ERBB2 Antibody V2W

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