Homo sapiens dystrobrevin binding protein 1 (DTNBP1), transcript variant 1
BLOC1S8; DBND; HPS7; My031; SDY
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of mouse Dtnbp1.
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
This antibody is purified through a protein A column, followed by peptide affinity purification. (Protein A or G Sepharose)
Guaranteed Application *
WB: 1: 10~50; IHC: 1:50~100; ELISA: 1: 1,000
Dtnp1 may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and binds to alpha- and beta-dystrobrevins, which are components of the dystrophin-associated protein complex (DPC). Mutations in this protein are associated with Hermansky-Pudlak syndrome type 7. This protein may also be associated with schizophrenia.
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Western blot analysis of Dtnbp1(arrow) using rabbit polyclonal Dysbindin(Dtnbp1) Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the Dtnbp1 gene (Lane 2)
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with Dtnbp1 Antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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