Home Antibody All anti-BUB1B antibodies
Also for BUB1B (NM_001211)
|This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the sequence of human BUB1B within aa 1-100.|
|Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.|
|Homo sapiens BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B)|
|Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1|
|BUB1B, a member of the Ser/Thr protein kinase family, is a probable component of the mitotic checkpoint that delays anaphase until all chromosomes are properly attached to the mitotic spindle. It can interact with BUB3, CENP-F, CENP-E and mitosin, and can be localized to nuclear kinetochores. This protein is highly expressed in thymus and spleen. The CD1 domain directs kinetochore localization and binding to BUB3. The protein possesses a cyclin destruction box sequence, which targets protein for rapid degradation by ubiquitin-dependent proteolysis during the transition from mitosis to interphase. Defects in BUB1B are associated with tumor formation.|
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HEK293T cells were transfected with the pCMV6-XL5 control or pCMV-BUB1B (SC119395) cDNA for 72 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-BUB1B Rabbit polyclonal Ab. The size markers are shown in numbers and the correct 120 kDa BUB1B protein is indicated by an arrow.