CSF1R is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy.
Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
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HEK293T cells were transfected with the pCMV6-XL5 control or pCMV-CSF1R (SC116882) cDNA for 72 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CSF1R Rabbit polyclonal Ab. The size markers are shown in numbers and the correct 107 kDa CSF1R protein doublet is indicated by two arrows.
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