Home All anti-STAT1 antibodies
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Also for STAT1 (NM_007315)
|A synthetic peptide corresponding to residues to the N-term of human Stat-1 was used as immunogen. This antibody will detect both alpha and beta isoforms.|
|Human, Mouse, Rat
||WB: 1: 1,000; IHC: 1:50-100
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens signal transducer and activator of transcription 1, 91kDa (STAT1), transcript variant alpha|
|CANDF7; ISGF-3; STAT91|
|Stat-1 is a latent transcription factor that functions both as a signal transducer in the cytoplasm and an activator of transcription in the nucleus. Stat-1 is one of seven members of the Signal transducer and activators of transcription (Stats) family (1). Stat-1 is activated by a different number of ligands; IFNa, IFN?, EGF, PDGF and IL6 (2-3). Upon tyrosine phosphorylation, Stat-1 dimerize with Stat-2 and associates with ISGF3/IR9 to form the ISGF3 complex (4). This activation subsequently allows the complex to translocate to the nucleus & bind specific enhancer elements. Additional complexes can form upon IFN stimulation. (1) |
EGFR1 Signaling Pathway
Jak-STAT signaling pathway
TGF Beta Signaling Pathway
Toll-like receptor signaling pathway
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HEK293T cells were transfected with the pCMV6-XL5 control or pCMV-STAT1 (SC115595) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-STAT1 Rabbit mAB. The size markers are shown in numbers and the correct 94 kD STAT1 protein is indicated by an arrow.
Western blot analysis on MCF7 cell lysate using anti-Stat-1 (N-term), dilution 1:1,000.
Immunohistochemical analysis of paraffin-embedded human prostate carcinoma using anti-STAT-1 (N-term)