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Anti-SYP Antibody EP1098Y
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|A synthetic peptide corresponding to residues in human Synaptophysin was used as an immunogen.|
|Human, Mouse, Rat
|WB, IHC, IF
||WB: 1:200,000; IHC: 1:250 500; ICC: 1:250 500; FC: 1:20; IP: 1:50
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens synaptophysin (SYP)|
|Synaptophysin is an integral membrane protein of small synaptic vesicles in brain and endocrine cells (1). Synaptophysin (syp I) is a synaptic vesicle membrane protein that constitutes approximately 7% of the total vesicle protein. Multiple lines of evidence implicate syp I in a number of nerve terminal functions (2). Synaptophysin is one of the most abundant membrane proteins of small synaptic vesicles. In mature nerve terminals it forms a complex with the vesicular membrane protein synaptobrevin, which appears to modulate synaptobrevin's interaction with the plasma membrane-associated proteins syntaxin and SNAP25 to form the SNARE complex as a prerequisite for membrane fusion. It has been shown that synaptobrevin is preferentially cleaved by tetanus toxin while bound to synaptophysin or when existing as a homodimer (3). data suggest that synaptophysin is released from the Golgi apparatus in a vesicular form, after glycosylation, and is then transported to nerve endings by a mechanism which requires integrity of microtubules (4). |
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Western blot analysis on rat brain membrane using anti-Synaptophysin, dilution 1:200,000.
Immunohistochemical staining of paraffin-embedded human medulloblastoma using anti-Synaptophysin.
Immunofluorescent staining of PC12 cells using anti-Synaptophysin.