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Anti-SUMO2 Antibody EPR4602
Also for SUMO2 (NM_001005849)
|A synthetic peptide corresponding to residues in human SUMO-2/3 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; ICC: 1:50 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens small ubiquitin-like modifier 2 (SUMO2), transcript variant 2|
|HSMT3; Smt3A; SMT3B; SMT3H2; SUMO3|
Entrez Gene 6613 Human
Entrez Gene 170930 Mouse
Entrez Gene 690244 Rat
|SUMO proteins and ubiquitin posttranslationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (1). SUMO-2/3 is a ubiquitin-like protein that can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer (2). Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I; it can be promoted by an E3 ligase (2). Moreover, SUMO-2/3 is expressed predominantly in the liver (2).|
|Druggable Genome |
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Western blot - Anti-Sumo 2+3 antibody [EPR4602]; All lanes : Anti-Sumo 2+3 antibody [EPR4602] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : 293T cell lysate.Lane 4 : SW480 cell lysate.Lane 5 : HL60 cell lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 11 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sumo 2+3 antibody [EPR4602]; TA307648 at 1/100 dilution, staining Sumo 2+3 in Human colon by Immunohistochemistry, Paraffin-embedded tissue.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Sumo 2 antibody [EPR4602]; TA307648 at 1/100 diltuion, staining Sumo 2+3 in Human hepatocellular carcinoma by Immunohistochemistry, Paraffin-embedded tissue.