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Anti-STAT6 Antibody YE361
Also for STAT6 (NM_003153)
|A synthetic peptide corresponding to residues near C-terminus of human Stat-6 was used as immunogen. The antibody does not cross-react with other Stat family members.|
||0.5~1.0 mg/ml (Lot Dependent)
|WB, IHC, IF
||WB: 1:2000; IHC-P: Use at an assay dependent concentration; ICC/IF: 1:100; IP: 1:80
|Does not react with Rat. Is unsuitable for Flow Cyt.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt.
|Homo sapiens signal transducer and activator of transcription 6, interleukin-4 induced (STAT6), transcript variant 2|
|D12S1644; IL-4-STAT; STAT6B; STAT6C|
|Janus family tyrosine kinases (Jaks) and signal transducers and activators of transcription (STATs) are involved in mediating gene expression in response to cytokines and interferons. Jaks associate with cytokine receptors; upon ligand binding, Jaks phosphorylate the receptor. The phosphorylated receptors are bound by SH2-containing proteins, one class of which is the STATs. Activated STATs, then, translocate to the nucleus to mediate gene transcription (1,2). Stat-6 is tyrosine phosphorylated in response to cellular interaction with IL-3 and IL-4 (3,4). |
Jak-STAT signaling pathway
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Western blot - STAT6 antibody [YE361]; Anti-STAT6 antibody [YE361] at 1/1000 dilution + NIH 3T3 cell lysate.Predicted band size : 94 kDa.Observed band size : 100 kDa .
Immunohistochemistry (Paraffin-embedded sections) - STAT6 antibody [YE361]; Immunohistochemical staining of paraffin-embedded human skin carcinoma using ab32520 at 1/100 dilution.
Immunocytochemistry/ Immunofluorescence - STAT6 antibody [YE361]; Immunofluorescent staining of HeLa cells using ab32520 at 1/100 dilution.