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Anti-STAT3 TRUEMAB Antibody Clone OTI21E7

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA500177 anti-STAT3 mouse monoclonal antibody, clone OTI21E7 (formerly 21E7) 100ul $379 In Stock
LC403728 STAT3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF500177 Carrier-free (BSA/glycerol-free) STAT3 mouse monoclonal antibody, clone OTI21E7 (formerly 21E7) 100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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WB(1)
IHC(8)
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Also for STAT3 (NM_213662)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenRecombinant protein expressed in E.coli corresponding to amino acids 154-175 of human stat3
Clone NameClone OTI21E7 IsotypeIgG1
Species ReactivityHuman Concentration0.35 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500, IHC 1:50
Predicted MW Explanation 88.08KDa
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 3
Alternative NameADMIO; APRF; HIES
Database LinkNP_998827
Entrez Gene 6774 Human
FunctionThe protein encoded by this gene is a member of the STAT protein family. In response to cytokinesand growth factors, STAT family members are phosphorylated by the receptor associated kinases, andthen form homo- or heterodimers that translocate to the cell nucleus where they act astranscription activators. This protein is activated through phosphorylation in response to variouscytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This proteinmediates the expression of a variety of genes in response to cell stimuli, and thus plays a keyrole in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has beenshown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor ofthis protein. Three alternatively spliced transcript variants encoding distinct isoforms have beendescribed
Related PathwayTranscription FactorsDruggable Genome Chemokine signaling pathwayJak-STAT signaling pathwayAdipocytokine signaling pathwayPathways in cancerPancreatic cancerAcute myeloid leukemiaMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY STAT3(RC212394) (RC212394, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-STAT3.
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Immunohistochemical staining of paraffin-embedded breast within the normal limits using anti-STAT3 (TA500177) mouse monoclonal antibody (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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Immunohistochemical staining of paraffin-embedded colon within the normal limits using anti-STAT3 (TA500177) mouse monoclonal antibody (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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Immunohistochemical staining of paraffin-embedded kidney within the normal limits using anti-STAT3 (TA500177) mouse monoclonal antibody (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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Immunohistochemical staining of paraffin-embedded Carcinoma of kidney using anti-STAT3 (TA500177) mouse monoclonal antibody (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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Immunohistochemical staining of paraffin-embedded lung within the normal limits using anti-STAT3 (TA500177) mouse monoclonal antibody (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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Immunohistochemical staining of paraffin-embedded Carcinoma of lung using anti-STAT3 (TA500177) mouse monoclonal antibody (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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Immunohistochemical staining of paraffin-embedded Carcinoma of pancreas using anti-STAT3 (TA500177) mouse monoclonal antibody (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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Immunohistochemical staining of paraffin-embedded thyroid within the normal limits using anti-STAT3 (TA500177) mouse monoclonal antibody (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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