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Home Antibody All anti-STAT3 antibodies

Anti-STAT3 Antibody EPR787Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301139
  • Rabbit Monoclonal Antibody against STAT3 (Clone EPR787Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403728) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for STAT3 (NM_213662)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to N-terminus residues of human Stat3 was used as immunogen.
Clone NameEPR787Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500; ICC: 1:50; IP: 1:30
Predicted MW Explanation 88 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 3
Alternative NameADMIO; APRF; HIES
Database LinkNP_998827
Entrez Gene 6774 Human
Entrez Gene 20848 Mouse
Entrez Gene 25125 Rat
FunctionStat3 is a member of a group of proteins (Signal Transduction and Activators of Transcription) that act as both signal transducers for cytokines and growth factors, as well as transcription factors (1,2). Stats are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus (1). Stat3 is constitutively activated in a number of human tumors (3). Stat3 is activated by phosphorylation on tyrosine 705 which induces dimerization, nuclear translocation, and DNA binding While, Stat3-activated transcription seems to be regulated by serine phosphorylation at serine 727 (4)
Related PathwayTranscription FactorsDruggable Genome Chemokine signaling pathwayJak-STAT signaling pathwayAdipocytokine signaling pathwayPathways in cancerPancreatic cancerAcute myeloid leukemiaMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - STAT3 antibody [EPR787Y]; All lanes : Anti-STAT3 antibody [EPR787Y] at 1/500 dilution.Lane 1 : A431 cell lysate.Lane 2 : Raji cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 88 kDa.Observed band size : 88 kDa.Additional bands at : 75 kDa. We are unsure as to the identity of these extra bands.

 

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