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Home Antibody All anti-STAT3 antibodies

Anti-STAT3 Antibody E121-21

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300380
  • Rabbit Monoclonal Antibody against STAT3 (Clone E121-21)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC403728) , 20ug
100ul 325 In Stock
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WB(1)
IHC(1)
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Also for STAT3 (NM_213662)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues surrounding Ser727 of human Stat3 was used as immunogen. The antibody only detects Stat3 without phosphorylation on Serine 727. It does not detect S727-phosphorylated Stat3. Predicted to cross-react with bovine, and horse, based on sequence homology.
Clone NameE121-21 IsotypeIgG
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsIHC-Fr: Use at an assay dependent concentration; WB: 1:1000; IHC-P: Use at an assay dependent dilution; IP: 1:20
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Protein A purified
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 3
Alternative NameAPRF; HIES
Database LinkNP_998827
FunctionStat3 is a member of a group of proteins (Signal Transduction and Activators of Transcription) that act as both signal transducers for cytokines and growth factors, as well as transcription factors (1,2). Stats are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus (1). Stat3 is constitutively activated in a number of human tumors (3). Stat3-activated transcription seems to be regulated by serine phosphorylation at Ser727 (4).
Related Pathway
Adipogenesis
Delta-Notch Signaling Pathway
EGFR1 Signaling Pathway
Jak-STAT signaling pathway
TGF Beta Signaling Pathway

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WB Image
Western blot - STAT3 antibody [E121-21]; Anti-STAT3 antibody [E121-21] at 1/1000 dilution + A431 cell lysate.Predicted band size : 88 kDa.Observed band size : 92 kDa .
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - STAT3 antibody [E121-21]; Immunohistochemical analysis of paraffin-embedded lung squamous carcinoma using TA300380 at a 1/50 dilution.

 

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