Stat-1 is a latent transcription factor that functions both as a signal transducer in the cytoplasm and an activator of transcription in the nucleus. Stat-1 is one of seven members of the Signal transducer and activators of transcription (Stats) family (1). Stat-1 is activated by a different number of ligands; IFN?, IFN?, EGF, PDGF and IL6 (2-3). Upon tyrosine phosphorylation, Stat-1 dimerize with Stat-2 and associates with ISGF3/IR9 to form the ISGF3 complex (4). This activation subsequently allows the complex to translocate to the nucleus & bind specific enhancer elements. Additional complexes can form upon IFN stimulation (1).
EGFR1 Signaling Pathway
Jak-STAT signaling pathway
TGF Beta Signaling Pathway
Toll-like receptor signaling pathway
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