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Home Antibody All anti-SPRED1 antibodies

Anti-SPRED1 Antibody

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SKU Description Amount Price Availability*  
TA306657
  • Rabbit Polyclonal Spred1 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC407400) , 20ug Explanation
100ug $325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenSpred1 antibody was raised against a 20 amino acid peptide near the center of the human Spred1.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens sprouty-related, EVH1 domain containing 1 (SPRED1)
Alternative NamehSpred1; NFLS; spred-1
Database LinkNP_689807
Entrez Gene 161742 Human
Entrez Gene 114715 Mouse
Entrez Gene 296072 Rat
FunctionThe Ras-MAP kinase pathway is essential for the differentiation of neuronal cells and myocytes; it is inhibited by Spred1, a member of the Sprouty family of proteins. Spred1 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). This Spred1 antibody is predicted to have no cross-reactivity to Spred2 or Spred3.
Related Pathway Jak-STAT signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of Spred1 in mouse brain tissue lysate with Spred1 antibody at (A) 1 and (B) 2 ug/ml.
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Immunohistochemistry of Spred1 in human brain tissue with Spred1 antibody at 2.5 ug/ml.
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