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Anti-SP1 Antibody EPR6662(B)
|A synthetic peptide corresponding to residues in human SP1 was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
|WB, ASSAY, IHC
||WB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; ICC/IF: 1:100 - 1:250
|pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 49% PBS, 50% Glycerol, 0.05% BSA|
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens Sp1 transcription factor (SP1), transcript variant 1|
|specificity protein 1; Sp1 transcription factor|
Entrez Gene 6667 Human
|Transcription factor SP1 is a member of the Sp/XKLF (Specificity protein/Krüppel-like factor) family. It regulates transcription by dynamically recruiting and forming complexes with many factors associated with transcription. Although SP1 has been described as a transcriptional activator, it can also act as a repressor (1). SP1 has been implicated in the expression of numerous genes involved in many aspects of cellular life such as metabolism, cell growth, differentiation, angiogenesis and apoptosis regulation (1). Although it is a ubiquitous protein that targets both core promoters and enhancers, SP1 is also highly expressed in various cancers of the stomach, colon and rectum, pancreas, breast, and thyroid (2).|
|Stem cell relevant signaling - JAK/STAT signaling pathwayES Cell Differentiation/IPSStem cell - PluripotencyTranscription FactorsDruggable Genome TGF-beta signaling pathwayHuntington's disease|
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Western blot - Anti-SP1 antibody [EPR6662(B)]; All lanes : Anti-SP1 antibody [EPR6662(B)] at 1/1000 dilution.Lane 1 : Ramos cell lysates.Lane 2 : HeLa cell lysates.Lane 3 : K562 cell lysates.Lane 4 : Raji cell lysates.Lysates/proteins at 10 ug per lane.Predicted band size : 81 kDa.
Other-Anti-SP1 antibody [EPR6662(B)](TA310869); Equilibrium disassociation constant (KD)..
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SP1 antibody [EPR6662(B)]; TA310869, at 1/100 dilution staining SP1 in paraffin-embedded Human colon tissue, by Immunohistochemistry.