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Anti-SP1 Antibody EPR6662(B)


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal antibody against SP1
100ul 325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human SP1 was used as an immunogen.
Clone NameEPR6662(B) IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; ICC/IF: 1:100 - 1:250
BufferpH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens Sp1 transcription factor (SP1), transcript variant 1
Alternative Namespecificity protein 1; Sp1 transcription factor
Database LinkNP_612482
Entrez Gene 6667 Human
FunctionTranscription factor SP1 is a member of the Sp/XKLF (Specificity protein/Krüppel-like factor) family. It regulates transcription by dynamically recruiting and forming complexes with many factors associated with transcription. Although SP1 has been described as a transcriptional activator, it can also act as a repressor (1). SP1 has been implicated in the expression of numerous genes involved in many aspects of cellular life such as metabolism, cell growth, differentiation, angiogenesis and apoptosis regulation (1). Although it is a ubiquitous protein that targets both core promoters and enhancers, SP1 is also highly expressed in various cancers of the stomach, colon and rectum, pancreas, breast, and thyroid (2).
Related PathwayStem cell relevant signaling - JAK/STAT signaling pathwayES Cell Differentiation/IPSStem cell - PluripotencyTranscription FactorsDruggable Genome TGF-beta signaling pathwayHuntington's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-SP1 antibody [EPR6662(B)]; All lanes : Anti-SP1 antibody [EPR6662(B)] at 1/1000 dilution.Lane 1 : Ramos cell lysates.Lane 2 : HeLa cell lysates.Lane 3 : K562 cell lysates.Lane 4 : Raji cell lysates.Lysates/proteins at 10 ug per lane.Predicted band size : 81 kDa.
Assay Image
Other-Anti-SP1 antibody [EPR6662(B)](TA310869); Equilibrium disassociation constant (KD)..
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SP1 antibody [EPR6662(B)]; TA310869, at 1/100 dilution staining SP1 in paraffin-embedded Human colon tissue, by Immunohistochemistry.


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