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Anti-SMURF2 Antibody EP629Y3
Also for SMURF2 (NM_022739)
|A synthetic peptide corresponding to residues in human Smurf2 was used as immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:500 - 1:1000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens SMAD specific E3 ubiquitin protein ligase 2 (SMURF2)|
Entrez Gene 64750 Human
Entrez Gene 66313 Mouse
Entrez Gene 303614 Rat
|Smad ubiquitination regulatory factor proteins (Smurf1 and Smurf2) are E3 ubiquitin ligase that belongs to the Hect family. Smurf proteins play an important role as regulators in TGF-beta pathway by ubiquitinating Smads and Smads associated proteins for proteasome degradation (1). Specifically, Smurf1 interacts with Smad1 and Smad5 for degradation, while Smurf2 ubiquitinates Smad1 and Smad2. Smads also functions to recruit Smurfs to various pathway components such as TGF-beta and SnoN. In particular, Smad7 acts as an adaptor protein between Smurfs and TGF-Beta receptors, allowing the receptors to be marked by Smurfs for degradation (2). Smurf2 interacts with all members of Smad family except for Smad4 and it is expressed various tissues and cell lines, such as placenta and ovarian cancer cell lines. Smurf2 has been implicated in the tumor formation and diseases progression (3). |
TGF Beta Signaling Pathway
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Western blot - SMURF 2 antibody [EP629Y3]; Anti-SMURF 2 antibody [EP629Y3] at 1/500 dilution + SH-SY-5Y cell lysate at 10 ug.Secondary.Goat anti-rabbit HRP labeled at 1/2000 dilution.Predicted band size : 86 kDa.Observed band size : 86 kDa.