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Home Antibody All anti-SMURF2 antibodies

Anti-SMURF2 Antibody EP629Y3

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300969
  • Rabbit Monoclonal Antibody against SMURF2 (Clone EP629Y3)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402939) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for SMURF2 (NM_022739)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Smurf2 was used as immunogen.
Clone NameEP629Y3 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500 - 1:1000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens SMAD specific E3 ubiquitin protein ligase 2 (SMURF2)
Alternative NameDKFZp686F0270; MGC138150
Database LinkNP_073576
Entrez Gene 64750 Human
Entrez Gene 66313 Mouse
Entrez Gene 303614 Rat
FunctionSmad ubiquitination regulatory factor proteins (Smurf1 and Smurf2) are E3 ubiquitin ligase that belongs to the Hect family. Smurf proteins play an important role as regulators in TGF-beta pathway by ubiquitinating Smads and Smads associated proteins for proteasome degradation (1). Specifically, Smurf1 interacts with Smad1 and Smad5 for degradation, while Smurf2 ubiquitinates Smad1 and Smad2. Smads also functions to recruit Smurfs to various pathway components such as TGF-beta and SnoN. In particular, Smad7 acts as an adaptor protein between Smurfs and TGF-Beta receptors, allowing the receptors to be marked by Smurfs for degradation (2). Smurf2 interacts with all members of Smad family except for Smad4 and it is expressed various tissues and cell lines, such as placenta and ovarian cancer cell lines. Smurf2 has been implicated in the tumor formation and diseases progression (3).
Related PathwayES Cell Differentiation/IPSAdult stem cellsTranscription FactorsDruggable Genome Ubiquitin mediated proteolysisEndocytosisTGF-beta signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - SMURF 2 antibody [EP629Y3]; Anti-SMURF 2 antibody [EP629Y3] at 1/500 dilution + SH-SY-5Y cell lysate at 10 ug.Secondary.Goat anti-rabbit HRP labeled at 1/2000 dilution.Predicted band size : 86 kDa.Observed band size : 86 kDa.

 

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