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Anti-SMAD7 Antibody EPR622
Also for SMAD7 (NM_001190821)
|A synthetic peptide corresponding to residues in human Smad7 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens SMAD family member 7 (SMAD7), transcript variant 2|
|CRCS3; MADH7; MADH8|
|Smad7 is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both Smad7 and TGFBR1. Expression of Smad7 is induced by TGFBR1. Variations in this protein are a cause of susceptibility to colorectal cancer type 3 (CRCS3) (1).|
TGF Beta Signaling Pathway
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Western blot - Anti-MADH7 antibody [EPR622]; All lanes : Anti-MADH7 antibody [EPR622] at 1/1000 dilution.Lane 1 : Human Uterus lysate.Lane 2 : Human Ovary Cancer lysate.Lane 3 : Human Fetal Lung lysate.Lane 4 : Human Skeletal Muscle lysate.Lane 5 : Human Kidney lysate.Lane 6 : Human Heart lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 46 kDa.
Other-Anti-MADH7 antibody [EPR622](ab124890); Equilibrium disassociation constant (KD)..