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Anti-SLC4A1 PHOSPHO Antibody EPR1424
Also for SLC4A1 (NM_000342)
|A phospho specific peptide corresponding to residues surrounding tyrosine 21 of human AE1 was used as an immunogen. This antibody only detects AE1 phosphorylated at tyrosine 21.|
||Tissue culture supernatant
||Lot dependent; please refer to CoA along with shipment
||WB: 1:50000 - 1:200000
|Does not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC,IHC-P or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens solute carrier family 4 (anion exchanger), member 1 (Diego blood group) (SLC4A1)|
|AE1; BND3; CD233; DI; EMPB3; EPB3; FR; RTA1A; SW; WD; WD1; WR|
|The AE1 (anion exchanger, band 3) protein is expressed in erythrocytes and in the A-type intercalated cells of the kidney distal collecting tubule. In both cell types it mediates the electroneutral transport of chloride and bicarbonate ions across the lipid bilayer, and, in erythrocytes (1). AE1 is phosphorylated on Tyr8and Tyr21 by SYK. It has been suggested that, upon phosphorylation by p72syk, Tyr8, and Tyr21 act as docking sites for the SH2 domain of Lyn, which subsequently phosphorylates AE1 at additional secondary sites (2).|
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Western blot - Anti-Band 3 (phospho Y21) antibody [EPR1424]; All lanes : Anti-Band 3 (phospho Y21) antibody [EPR1424] at 1/50000 dilution.Lane 1 : Human red blood cell lysate, untreated.Lane 2 : Human red blood cell lysate, Pervanadate treated.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.developed using the ECL technique.Predicted band size : 101 kDa.