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Anti-SLAMF1 Antibody 9D1
Also for SLAMF1 (NM_013730)
||0.5-1mg/ml (lot dependent)
||Flow, Functional Assay
|Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Mus musculus signaling lymphocytic activation molecule family member 1 (Slamf1)|
|4933415F16; AA177906; CD150; CDw150; ESTM51; IPO-3; Slam|
|The 9D1 monoclonal antibody reacts with mouse CD150, an ~70 kDa transmembrane glycoprotein also known as Signaling Lymphocyte Activation Molecule (SLAM). CD150 is expressed by T (especially TH1) and B cells and its expression is rapidly upregulated on these cells upon activation. Immature thymocytes and dendritic cells also express this antigen. Signaling through SLAM in T cells induces proliferation and augmentation of the interferon-gamma response. Furthermore, SLAM is thought to play a role in adhesion between the T cell and antigen-presenting cell. 9D1 is reported to be an activating antibody.Mouse hematopoietic stem cells (HSC) can be identified using SLAM family markers, such as CD150+CD244-CD48-. For this application we recommend the use of antibody clone mShad150 (cat. 12-1502).|
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Staining of C57BL/6 splenocytes with 0.5 ug of Rat IgG1 kappa Isotype Control Purified (open histogram) or 0.5 ug of Anti-Mouse CD150 Purified (filled histogram) followed by Anti-Rat IgG Biotin and Streptavidin PE . Cells in the lymphocyte gate were used for analysis.