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Home Antibody All anti-SKIL antibodies

Anti-SKIL Antibody


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SKU Description Amount Price Availability*  
TA306034 Rabbit Polyclonal SnoN Antibody 100ug $325 3-7 Days
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OriGene Data

ImmunogenSnoN antibody was raised against a 16 amino acid peptide from near the amino terminus of human SnoN .
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 0.5 - 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens SKI-like proto-oncogene (SKIL), transcript variant 2
Alternative NameSNO; SnoA; SnoI; SnoN
Database LinkNP_001138569
Entrez Gene 6498 Human
Entrez Gene 20482 Mouse
Entrez Gene 114208 Rat
FunctionTGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells. There are at least four alternately spliced isoforms of SnoN; SnoN antibody will recognize all isoforms (SnoN, SnoN2, SnoI, and SnoA).
Related PathwayTranscription FactorsDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of SnoN in A431 cell lysate with SnoN antibody at (A) 0.5 and (B) 1 ug/ml.

IHC Image
Immunohistochemistry of SnoN in mouse lung tissue with SnoN antibody at 5 ug/ml.

IF Image
Immunofluorescence of SnoN in Mouse Lung cells with SnoN antibody at 20 ug/mL.


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