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Home Antibody All anti-SHH antibodies

Anti-SHH TRUEMAB Antibody clone 3A2

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA500040
  • anti-SHH (Sonic Hedgehog) mouse monoclonal antibody, clone 3A2
  • FREE positive control: HEK293T cell transient overexpression lysate (LC424868) , 20ug
100ul 325 In Stock
CF500040
  • Carrier-free (BSA/glycerol-free) SHH mouse monoclonal antibody,clone 3A2
100ug $450 3-4 weeks
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WB(1)
IF(1)
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Also for SHH (NM_000193)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRecombinant protein expressed in E.coli corresponding to amino acids 24-197 of human SHH
Clone Nameclone 3A2 IsotypeIgG2a
Species ReactivityHuman Concentration0.12mg/ml
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:2000, IF (1:100)
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens sonic hedgehog (SHH)
Alternative NameHHG1; HLP3; HPE3; MCOPCB5; SMMCI; TPT; TPTPS
Database LinkNP_000184
FunctionSHH is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo.
Related Pathway
Hedgehog signaling pathway

* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SHH(RC222175) (RC222175, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SHH.
IF Image
Anti-SHH mouse monoclonal antibody (TA500040) immunofluorescent staining (Red) of COS7 cells transiently transfected by pCMV6-ENTRY SHH(RC222175).

 

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