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Home Antibody All anti-SHC1 antibodies

Anti-SHC1 TRUEMAB Antibody Clone OTI3H1

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA501103 anti-SHC1 (SHC) mouse monoclonal antibody, clone OTI3H1 (formerly 3H1) 100ul $325 In Stock
LC401060 SHC1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF501103 Carrier-free (BSA/glycerol-free) SHC1 mouse monoclonal antibody, clone OTI3H1 (formerly 3H1) 100ug $450 3-4 weeks
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WB(1)
IF(1)
FC(1)

OriGene Data

ImmunogenFull length human recombinant protein of human SHC1 (NP_003020) produced in HEK293T cell.
Clone NameClone OTI3H1 IsotypeIgG1
Species ReactivityHuman Concentration0.86 mg/ml
Guaranteed Application *WB, IF, FC Suggested DilutionsWB 1:2000, IF 1:100, Flow 1:100
Predicted MW Explanation 51.5kDa
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens SHC (Src homology 2 domain containing) transforming protein 1 (SHC1), transcript variant 2
Alternative NameSHC; SHCA
Database LinkNP_003020
Entrez Gene 6464 Human
FunctionSignaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span
Related PathwayDruggable Genome ErbB signaling pathwayChemokine signaling pathwayFocal adhesionNatural killer cell mediated cytotoxicityNeurotrophin signaling pathwayInsulin signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SHC1 (RC204362, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SHC1.
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Anti-SHC1 mouse monoclonal antibody (TA501103) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SHC1(RC204362).
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HEK293T cells transfected with either pCMV6-ENTRY SHC1(RC204362)(Red) or empty vector control plasmid(Blue) were immunostained with anti-SHC1 mouse monoclonal(TA501103), and then analyzed by flow cytometry.
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