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Home Antibody All anti-SHC1 antibodies

Anti-SHC1 TRUEMAB Antibody clone 3A1

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (1) Related Products Product Documents
SKU Description Amount Price Availability*  
TA501056
  • anti-SHC1 (SHC) mouse monoclonal antibody, clone 3A1
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401060) , 20ug
100ul 379 In Stock
CF501056
  • Carrier-free (BSA/glycerol-free) SHC1 mouse monoclonal antibody, clone 3A1
100ug $450 3-4 Days
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WB(1)
IHC(8)
IF(1)
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Also for SHC1 (NM_003029)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human SHC1 (NP_003020) produced in HEK293T cell.
Clone Nameclone 3A1 IsotypeIgG1
Species ReactivityHuman Concentration1.00 mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB 1:2000, IHC 1:50, IF 1:100,
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.06% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens SHC (Src homology 2 domain containing) transforming protein 1 (SHC1), transcript variant 2
Alternative NameSHC; SHCA
Database LinkNP_003020
FunctionSignaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span
Related Pathway
EGFR1 Signaling Pathway
Focal Adhesion
Hemostasis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SHC1 (RC204362, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SHC1.
IHC Image
Immunohistochemical staining of paraffin-embedded breast tissue using anti-SHC1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA501056, Dilution 1:50)
IHC Image
Immunohistochemical staining of paraffin-embedded colon tissue using anti-SHC1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA501056, Dilution 1:50)
IHC Image
Immunohistochemical staining of paraffin-embedded Kidney tissue using anti-SHC1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA501056, Dilution 1:50)
IHC Image
Immunohistochemical staining of paraffin-embedded Carcinoma of liver tissue using anti-SHC1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA501056, Dilution 1:50)
IHC Image
Immunohistochemical staining of paraffin-embedded lung tissue using anti-SHC1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA501056, Dilution 1:50)
IHC Image
Immunohistochemical staining of paraffin-embedded prostate tissue using anti-SHC1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA501056, Dilution 1:50)
IHC Image
Immunohistochemical staining of paraffin-embedded Carcinoma of prostate tissue using anti-SHC1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA501056, Dilution 1:50)
IHC Image
Immunohistochemical staining of paraffin-embedded bladder tissue using anti-SHC1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA501056, Dilution 1:50)
IF Image
Anti-SHC1 mouse monoclonal antibody (TA501056) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SHC1(RC204362).

 

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