The human Src homology and collagen (SHC) gene encodes for three proteins (p46, p52, p66). All three SHC isoforms are known to be signaling adaptors that couple activated growth factor receptors to their signaling pathways. p52 and p46 are expressed in every cell type while p66 expression varies from cell type to cell type (1-3). Upon stimulation by tyrosine kinase receptors and cytoplasmic TKs, all three SHCs become phosphorylated. Once phosphorylated, p52, p46 and p66 recruit and form a stable complex with GRB2/SOS. p52 and p46 activate the Ras and MAP kinase pathway, while p66 is involved in a signal transduction pathway that regulates the cellular response to oxidative stress and life span (4-5).
EGFR1 Signaling Pathway
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