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Home Antibody All anti-SH3BP2 antibodies

Anti-SH3BP2 PHOSPHO Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319445
  • Rabbit polyclonal SH3BP2 phospho S427 antibody (Phospho-specific)
100ug 325 3-7 Days
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WB(1)
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Also for SH3BP2 (NM_006656)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenThis affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding aa 422-433 of Human SH3BP3 protein (SH3 Domain Binding Protein 2).
Clone Name IsotypeIgG
Species Reactivityhuman, mouse, rat Concentration1.0 mg/mL
Guaranteed Application *WB Suggested DilutionsELISA: 1:2,000 - 1:10,000, WB: 1:500 - 1:2,000, IP: 1:100
Buffer0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Note SH3BP2 Src Homology 3 Binding Protein 2 is also known as 3BP-2 and SH3 Binding Protein 2. The Src homology 3 (SH3) region is a small protein domain presented in a very large group of proteins, including cytoskeletal elements and signaling proteins. SH3 domains are believed to serve as modules that mediate protein-protein associations and, along with Src homology 2 (SH2) domains, regulate cytoplasmic signaling. SH3BP2 is composed of an N terminal pleckstrin homology (PH) domain, a ten aa SH3 binding domain, three modular peptide recognition domains, and a C terminal SH2 domain. SH3BP2 function relates to signal transduction and regulation. SH3BP2 binds differentially to the SH3 domains of certain proteins of signal transduction pathways.   Phosphorylation of SH3BP2 occurs on S427 for activation. SH3BP2 mediates interactions of huntingtin and MLK2 (mixed lineage kinase). Defects in SH3BP2 are the cause of cherubism (CRBM), an autosomal dominant inherited syndrome. It is characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.

Reference Data

Target NameHomo sapiens sialidase 3 (membrane sialidase) (NEU3)
Alternative NameSIAL3
Database LinkNP_006647
Entrez Gene 10825 Human
Entrez Gene 50877 Mouse
Entrez Gene 117185 Rat
Function
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis is shown using Affinity Purified anti-SH3BP2 pS427 antibody to detect endogenous protein present in unstimulated human whole cell lysates).  The band as indicated by the arrowheads is evident in both M059 cells (panel A) and PC-3 cells (panel B).  Comparison to a molecular weight marker indicates a band of ~60 kDa corresponding to human SH3BP2 protein.  The blot was incubated with a 1:500 dilution of the antibody at room temperature followed by detection using standard techniques.  Personal communication Steven Pelech, Kinexus Inc.

 

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