Sentrin-specific protease 1 (SENP1) is a protease that catalyzes several essential functions in the small ubiquitin-like modifier protein (SUMO) pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms; deconjugation of SUMO1, SUMO2 and SUMO3 from protein targets; and depolymerization of SUMO’s conjugated within polymeric chains (1). Therefore, SENP1 regulates the sumoylation state of target proteins in cells during post-translational modification (2). This process involves cellular functions such as gene transcription, nucleocytoplasmic transport, and signal transduction (3). SENP1 also contains conserved C-terminal domains with unique specificities that catalyze protease activity (4). It is highly expressed in the testis and is also expressed at lower levels in the thymus, pancreas, and spleen (1).
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