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Anti-SENP1 Antibody EPR3844


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SKU Description Amount Price Availability*  
  • Rabbit monoclonal antibody against SENP1(clone EPR3844)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402347) , 20ug Explanation
100ul $325 3 Weeks
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human SENP1 was used as an immunogen.
Clone NameEPR3844 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsICC/IF: 1:500; WB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250; ICC: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens SUMO1/sentrin specific peptidase 1 (SENP1)
Alternative NameSuPr-2
Database LinkNP_055369
Entrez Gene 29843 Human
FunctionSentrin-specific protease 1 (SENP1) is a protease that catalyzes several essential functions in the small ubiquitin-like modifier protein (SUMO) pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms; deconjugation of SUMO1, SUMO2 and SUMO3 from protein targets; and depolymerization of SUMO’s conjugated within polymeric chains (1). Therefore, SENP1 regulates the sumoylation state of target proteins in cells during post-translational modification (2). This process involves cellular functions such as gene transcription, nucleocytoplasmic transport, and signal transduction (3). SENP1 also contains conserved C-terminal domains with unique specificities that catalyze protease activity (4). It is highly expressed in the testis and is also expressed at lower levels in the thymus, pancreas, and spleen (1).
Related PathwayProteaseDruggable Genome

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Western blot - SENP1 antibody [EPR3844]; All lanes : Anti-SENP1 antibody [EPR3844] at 1/1000 dilution.Lane 1 : HeLa cell lysates .Lane 2 : HUVEC cell lysates .Lane 3 : Jurkat cell lysates .Lane 4 : Daudi cell lysates.Lane 5 : U87-MG cell lysates .Lysates/proteins at 10 ug per lane.Secondary.Standard HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 73 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - SENP1 antibody [EPR3844]; Immunohistochemical analysis of paraffin-embedded Human testis tissue using TA307104
Immunocytochemistry/ Immunofluorescence - Anti-SENP1 antibody [EPR3844]; TA307104 (1/500) staining SENP1 in HeLa cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.5% Triton X-100/PBS and counterstained with DAPI in order to highlight the nucleus (red).


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