Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
Homo sapiens SUMO1/sentrin specific peptidase 1 (SENP1)
Synonyms:
SuPr-2
Immunogen
A synthetic peptide corresponding to residues in human SENP1 was used as an immunogen.
Buffer
Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Sentrin-specific protease 1 (SENP1) is a protease that catalyzes several essential functions in the small ubiquitin-like modifier protein (SUMO) pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms; deconjugation of SUMO1, SUMO2 and SUMO3 from protein targets; and depolymerization of SUMO’s conjugated within polymeric chains (1). Therefore, SENP1 regulates the sumoylation state of target proteins in cells during post-translational modification (2). This process involves cellular functions such as gene transcription, nucleocytoplasmic transport, and signal transduction (3). SENP1 also contains conserved C-terminal domains with unique specificities that catalyze protease activity (4). It is highly expressed in the testis and is also expressed at lower levels in the thymus, pancreas, and spleen (1).
Related Pathway
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