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Anti-SELL Antibody MEL-14
Also for SELL (NM_011346)
||0.5-1mg/ml (lot dependent)
||Flow, IHC, Functional Assay, IP
|Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Affinity purified (Protein A or G Sepharose)
|Mus musculus selectin, lymphocyte (Sell), transcript variant 1|
|AI528707; CD62L; L-selectin; LECAM-1; Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1|
|The MEL-14 monoclonal antibody reacts with mouse CD62L, a 76 kDa member of the selectin family. CD62L is expressed by neutrophils, monocytes, and subsets of T, B, and NK cells and binds a number of glycosylated, fucosylated, sulfated sialylated glycoproteins including CD34, glycam-1 and MAdCam-1. These interactions mediate rolling of lymphocytes on activated endothelium at the sites of inflammation and homing of cells to the high endothelial venules (HEV) of peripheral lymphoid tissues.|
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Staining of BALB/c splenocytes with 0.25 ug of Rat IgG2a kappa Isotype Control Purifed (open histogram) or 0.25 ug of Anti-Mouse CD62L (L-Selectin) Purified (filled histogram) followed by Anti-Rat IgG FITC . Cells in the lymphocyte gate were used for analysis.