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Home Antibody All anti-SCARB2 antibodies

Anti-SCARB2 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306583
  • Rabbit Polyclonal LIMP2 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401685) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for SCARB2 (NM_005506)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenLIMP2 antibody was raised against a 16 amino acid peptide from near the center of human LIMP2.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 - 2 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens scavenger receptor class B, member 2 (SCARB2), transcript variant 1
Alternative NameAMRF; CD36L2; EPM4; HLGP85; LGP85; LIMP-2; LIMPII; SR-BII
Database LinkNP_005497
FunctionThe lysosomal integral membrane protein 2 (LIMP2) is a heavily glycosylated type III transmembrane protein, the majority of which exists in the lumen of the lysosome and a cytoplasmic domain of approximately 20 amino acids. A deficiency of LIMP2 in mice causes uretic pelvic junction obstruction, deafness, and peripheral neuropathy associated with impaired vesicular trafficking and distribution of apically expressed proteins. More recently, LIMP2 was shown to act as a receptor to bind b-glucocerebrosidase, the enzyme defective in Gaucher disease, a lysosomal storage disorder. LIMP2-deficient mice showed missorted as well as secreted b-glucocerebrosidase, suggesting that LIMP2 also functions as the mannose-6-phosphate-independent trafficking receptor. Despite its predicted molecular weight, LIMP2 runs at approximately 80 – 85 kDa in SDS-PAGE.
Related Pathway

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WB Image
Western blot analysis of LIMP2 in human skeletal muscle tissue lysate with LIMP2 antibody at 1 ug/ml in (A) the absence and (B) presence of blocking peptide.
IHC Image
Immunohistochemistry of LIMP2 in human skeletal muscle with LIMP2 antibody at 2.5 ug/ml.

 

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