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Also for SAFB (NM_002967)
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 476 and 705 of HET/ SAF B|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens scaffold attachment factor B (SAFB), transcript variant 3|
|HAP; HET; SAF-B1; SAFB1|
|This gene encodes a DNA-binding protein that has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. This encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of the heat shock protein 27 transcription and also can act as an estrogen receptor corepressor. This gene is a candidate gene for breast tumorigenesis. [provided by RefSeq]|
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A: A431 B: HepG2 (anti-SAFB antibody diluted at 1:1000)
Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using Scaffold attachment factor B1(anti-SAFB antibody) antibody at 1:100 dilution.