Home Antibody All anti-Rcan2 antibodies
Also for Rcan2 (NM_005822)
|RCAN2 antibody was raised against a 14 amino acid peptide near the center of human RCAN2.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens regulator of calcineurin 2 (RCAN2), transcript variant 1|
|CSP2; DSCR1L1; MCIP2; RCN2; ZAKI-4; ZAKI4|
|Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin’s activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.|
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Western blot analysis of RCAN2 in 3T3 cell lysate with RCAN2 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of RCAN2 in mouse brain tissue with RCAN2 antibody at 2.5 ug/mL.