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Anti-RYBP Antibody


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SKU Description Amount Price Availability*  
  • Rabbit Polyclonal DEDAF Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC415887) , 20ug Explanation
100ug 325 In Stock
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Also for RYBP (NM_012234)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenDEDAF antibody was raised against a synthetic peptide corresponding to amino acids 215 to 228 of human DEDAF. The sequence is identical to that of mouse origin.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens RING1 and YY1 binding protein (RYBP)
Alternative NameAAP1; DEDAF; YEAF1
Database LinkNP_036366
Entrez Gene 23429 Human
Entrez Gene 56353 Mouse
Entrez Gene 312603 Rat
FunctionApoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD) death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. Several molecules including caspases and adaptor FADD contain DEDs. A novel protein that interacts with DED of caspase-8 and 10, and FADD was identified recently and designated DEDAF for DED associated factor . DEDAF is identical to the transcriptional repressor RYBP (2). DEDAF/RYBP is expressed in multiple tissues and cell lines. DEDAF interacts with FADD and augments the formation of CD95/FADD/capase-8 complexes at the cell membrane, and interacts with DED-containing DNA biding protein (DEDD) in the nucleus indicating it is involved in the regulation of both cytoplasmic and nuclear events of apoptosis.
Related PathwayTranscription FactorsDruggable Genome

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WB Image
Western blot analysis of DEDAF expression in human A549 (lane A), HepG2 (lane B), and mouse 3T3 (lane C) cell lysates with DEDAF antibody at 1 ug /ml.
IHC Image
Immunohistochemistry of DEDAF in mouse liver tissue with DEDAF antibody at 10 ug/ml.


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