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Home Antibody All anti-RWDD3 antibodies

Anti-RWDD3 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306847
  • Rabbit Polyclonal RWDD3 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC426894) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
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Also for RWDD3 (NM_001128142)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRWDD3 antibody was raised against a 17 amino acid peptide from near the amino terminus of human RWDD3.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB Suggested DilutionsWB: 0.5 - 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens RWD domain containing 3 (RWDD3), transcript variant 2
Alternative NameRSUME
Database LinkNP_001121614
Entrez Gene 25950 Human
Entrez Gene 66568 Mouse
Entrez Gene 65026 Rat
FunctionRWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune–inflammatory signals. RWDD3 increases Ikbeta sumoylation and stability. In addition, RWDD3 inhibits TNF-alpha-induced kB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikbeta increased stability. RSUME-enhanced sumoylation of Ikbeta leads to the inhibition of NF-kbeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of RWDD3 in mouse kidney tissue lysate with RWDD3 antibody at 0.5 µg/ml in (A) the absence and (B) the presence of blocking peptide.

 

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