Home Antibody All anti-RWDD3 antibodies
Also for RWDD3 (NM_001128142)
|RWDD3 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human RWDD3.|
|Human, Mouse, Rat
||WB: 1 - 2 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens RWD domain containing 3 (RWDD3), transcript variant 2|
Entrez Gene 25950 Human
Entrez Gene 66568 Mouse
Entrez Gene 65026 Rat
|RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune–inflammatory signals. RWDD3 increases Ikbeta sumoylation and stability. In addition, RWDD3 inhibits TNF-alpha-induced kB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikbeta increased stability. RSUME-enhanced sumoylation of Ikbeta leads to the inhibition of NF-kbeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.|
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Western blot analysis of RWDD3 in rat kidney tissue lysate with RWDD3 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.