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Anti-RUVBL1 Antibody EPR4143
Also for RUVBL1 (NM_003707)
|A synthetic peptide corresponding to residues in human RUVBL1 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC or IHC-P.
|Homo sapiens RuvB-like AAA ATPase 1 (RUVBL1)|
|ECP54; INO80H; NMP238; PONTIN; Pontin52; RVB1; TIH1; TIP49; TIP49A|
|RUVBL1, also known as TIP49A, is a member of the AAA+ family and component of the NuA4 histone acetyltransferase complex, which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (1, 2, 3). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins, positively regulating transcription (2). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction; tumor suppressor mediated growth arrest and replicative senescence; apoptosis; and double-strand break repair (2). RUVBL1 is ubiquitously expressed with high expression in the heart, skeletal muscle and testis (2).|
Wnt Signaling Pathway
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Western blot - TIP49A antibody [EPR4143]; All lanes : Anti-TIP49A antibody [EPR4143] at 1/1000 dilution.Lane 1 : K562 cell lysate.Lane 2 : 293T cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 50 kDa.