RUNX2 is a member of the RUNX family of transcription factors and is a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. It can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in RUNX2 have been associated with the bone development disorder cleidocranial dysplasia (CCD) (1).
TGF Beta Signaling Pathway
Wnt Signaling Pathway
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