Anti-RUNX2 Antibody, EPR6544

Also for RUNX2 (NM_001015051)

Gene Name	Homo sapiens runt-related transcription factor 2 (RUNX2), transcript variant 2
Synonyms:	AML3; CBFA1; CCD; CCD1; OSF-2; OSF2; PEA2aA; PEBP2A1; PEBP2A2; PEBP2aA; PEBP2aA1
Immunogen	A synthetic peptide corresponding to residues in human RUNX2 was used as an immunogen.
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Clone Name	EPR6544	Isotype
Species Reactivity	Human, Mouse, Rat	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB	Suggested Dilutions	WB: 1:1,000 - 10,000;
Background	RUNX2 is a member of the RUNX family of transcription factors and is a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. It can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in RUNX2 have been associated with the bone development disorder cleidocranial dysplasia (CCD) (1).
Related Pathway	TGF Beta Signaling Pathway Wnt Signaling Pathway

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WB Image

Western blot analysis on (A) K562 and (B) RAW 264.7 cell lysates using anti-RUNX2 RabMAb.

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Anti-RUNX2 Antibody EPR6544

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