Home Antibody All anti-RUNX1T1 antibodies
Anti-RUNX1T1 TRUEMAB Antibody Clone 1H1
TrueMAB Antibodies - Made against Authentic Protein Antigens
Also for RUNX1T1 (NM_175635)
|Full length human recombinant protein of human RUNX1T1(NP_783553) produced in HEK293T cell.|
||WB 1:2000, IF 1:100,
|PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography
|Homo sapiens runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (RUNX1T1), transcript variant 3|
|AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2|
Entrez Gene 862 Human
|This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq]. |
|Transcription Factors Pathways in cancerAcute myeloid leukemia|
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RUNX1T1 (RC222426, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RUNX1T1.
Western blot analysis of extracts (10ug) from 7 different cell lines by using anti-RUNX1T1 monoclonal antibody at 1:200 dilution.
Anti-RUNX1T1 mouse monoclonal antibody (TA504703) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY RUNX1T1(RC222426).