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Anti-RPS6KB1 PHOSPHO Antibody EPR2132
Also for RPS6KB1 (NM_003161)
|A phospho specific peptide corresponding to residues surrounding serine 371 of human p70 S6 Kinase was used as an immunogen. This antibody only detects p70 S6 Kinase phosphorylated at serine 371.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens ribosomal protein S6 kinase, 70kDa, polypeptide 1 (RPS6KB1), transcript variant 1|
|p70 S6KA; p70(S6K)-alpha; p70-alpha; p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A|
|p70 S6 Kinase is a mitogen-activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression (1). p70 S6 kinase phosphorylates specifically ribosomal protein S6. Activation of p70 S6 kinase is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains (2). Activation occurs via phosphorylation at Ser411, Thr421 and Ser424 within the pseudosubstrate region (3, 4). Phosphorylation of Thr229 in the catalytic domain and Thr389 in the linker domain are most critical for kinase function (2).|
TGF Beta Signaling Pathway
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Western blot - P70 S6 Kinase beta (phospho S371) antibody [EPR2132]; All lanes : Anti-P70 S6 Kinase beta (phospho S371) antibody [EPR2132] at 1/1000 dilution.Lane 1 : 293T cell lysate, untreated.Lane 2 : 293T cell lysate, treated with Alkaline Phosphatase (AP).Lysates/proteins at 10 µg per lane.Predicted band size : 53 kDa.