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Home Antibody All anti-RPS6KB1 antibodies

Anti-RPS6KB1 PHOSPHO Antibody EPR2132

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307384
  • Rabbit monoclonal antibody against p70 S6 Kinase Phospho (pS371)(clone EPR2132) (Phospho-Specific)
100ul 325 In Stock
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WB(1)
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Also for RPS6KB1 (NM_003161)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding serine 371 of human p70 S6 Kinase was used as an immunogen. This antibody only detects p70 S6 Kinase phosphorylated at serine 371.
Clone NameEPR2132 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
Predicted MW Explanation 53 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens ribosomal protein S6 kinase, 70kDa, polypeptide 1 (RPS6KB1), transcript variant 1
Alternative Namep70 S6KA; p70(S6K)-alpha; p70-alpha; p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A
Database LinkNP_003152
Entrez Gene 6198 Human
Entrez Gene 72508 Mouse
Entrez Gene 83840 Rat
Functionp70 S6 Kinase is a mitogen-activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression (1). p70 S6 kinase phosphorylates specifically ribosomal protein S6. Activation of p70 S6 kinase is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains (2). Activation occurs via phosphorylation at Ser411, Thr421 and Ser424 within the pseudosubstrate region (3, 4). Phosphorylation of Thr229 in the catalytic domain and Thr389 in the linker domain are most critical for kinase function (2).
Related PathwayProtein KinaseDruggable Genome ErbB signaling pathwaymTOR signaling pathwayTGF-beta signaling pathwayFc gamma R-mediated phagocytosisInsulin signaling pathwayAcute myeloid leukemiaMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - P70 S6 Kinase beta (phospho S371) antibody [EPR2132]; All lanes : Anti-P70 S6 Kinase beta (phospho S371) antibody [EPR2132] at 1/1000 dilution.Lane 1 : 293T cell lysate, untreated.Lane 2 : 293T cell lysate, treated with Alkaline Phosphatase (AP).Lysates/proteins at 10 ug per lane.Predicted band size : 53 kDa.

 

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