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Home Antibody All anti-RPS6KB1 antibodies

Anti-RPS6KB1 Antibody E135

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300301
  • Rabbit Monoclonal Antibody against RPS6KB1 (Clone E135)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401097) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for RPS6KB1 (NM_003161)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Thr421 and Ser424 of human p70 S6 Kinase alpha was used as immunogen. The antibody only detects p70-S6K phosphorylated on Threonine 421 and Serine 424. Predicted to cross-react with rat and
Clone NameE135 IsotypeIgG
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:2,500; IP: 1:20
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification IgG fraction
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens ribosomal protein S6 kinase, 70kDa, polypeptide 1 (RPS6KB1), transcript variant 1
Alternative Namep70 S6KA; p70(S6K)-alpha; p70-alpha; p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A
Database LinkNP_003152
Functionp70 S6 Kinase is a mitogen-activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression (1). p70 S6 kinase phosphorylates specifically ribosomal protein S6. Activation of p70 S6 kinase is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains (2). Activation occurs via phosphorylation at Ser411, Thr421 and Ser424 within the pseudosubstrate region (3, 4).
Related Pathway
TGF Beta Signaling Pathway

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WB Image
Western blot - P70 S6 Kinase (phospho T421 + S424) antibody [E135]; All lanes : Anti-S6K1 (phospho T421 + S424) antibody [E135] at 1/2500 dilution.Lane 1 : 293T cell lysate, untreated.Lane 2 : 293T cell lysate, treated with EGF.Predicted band size : 59 kDa.Observed band size : 70 kDa .

 

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