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Anti-RPS6KB1 Antibody E135
Also for RPS6KB1 (NM_003161)
|A synthetic phospho-peptide corresponding to residues surrounding Thr421 and Ser424 of human p70 S6 Kinase alpha was used as immunogen. The antibody only detects p70-S6K phosphorylated on Threonine 421 and Serine 424. Predicted to cross-react with rat and|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:2,500; IP: 1:20
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|IgG fraction (Protein A or G Sepharose)
|Does not react with Mouse, Rat
|Homo sapiens ribosomal protein S6 kinase, 70kDa, polypeptide 1 (RPS6KB1), transcript variant 1|
|p70 S6KA; p70(S6K)-alpha; p70-alpha; p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A|
|p70 S6 Kinase is a mitogen-activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression (1). p70 S6 kinase phosphorylates specifically ribosomal protein S6. Activation of p70 S6 kinase is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains (2). Activation occurs via phosphorylation at Ser411, Thr421 and Ser424 within the pseudosubstrate region (3, 4).|
TGF Beta Signaling Pathway
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Western blot - P70 S6 Kinase (phospho T421 + S424) antibody [E135]; All lanes : Anti-S6K1 (phospho T421 + S424) antibody [E135] at 1/2500 dilution.Lane 1 : 293T cell lysate, untreated.Lane 2 : 293T cell lysate, treated with EGF.Predicted band size : 59 kDa.Observed band size : 70 kDa .