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Anti-RPS6KA6 Antibody EP1982Y
Also for RPS6KA6 (NM_014496)
|A synthetic peptide corresponding to residues near the N-terminus of human Rsk 4 was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
|WB, IHC, IF
||WB: 1:250 - 1:500; FC: 1:25; ICC/IF: 1:100 - 1:250; IHC-P: 1:50 - 1:100
|Does not react with Mouse, Rat. Is unsuitable for IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for IP.
|Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 6 (RPS6KA6)|
|RSK4 is a member of the family of 90-kDa ribosomal S6 kinases (1). These proteins are a class of serine/threonine kinases that are activated in response to various extracellular signals, including growth factors, polypeptide hormones and neurotransmitters (2). RSK4 is most abundantly expressed in brain and kidney. The predicted protein of 746 amino acids shows a high level of homology to three previously isolated members of the human RSK family. RSK2 is involved in Coffin-Lowry syndrome and nonspecific MRX. The localization of RSK4 in the interval that is commonly deleted in mentally retarded males together with the high degree of amino acid identity with RSK2 suggests that RSK4 plays a role in normal neuronal development (3). |
MAPK signaling pathway
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Western blot - RSK4 antibody [EP1982Y] - N-terminal; Anti-RSK4 antibody [EP1982Y] - N-terminal at 1/500 dilution + SH-SY5Y cell lysate at 10 µg.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 84 kDa.Observed band size : 90 kDa .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - RSK4 antibody [EP1982Y] - N-terminal; ab76117, at 1/50 dilution, staining RSK4 in paraffin-embedded human brain glioma tissue.
Immunocytochemistry/ Immunofluorescence - RSK4 antibody [EP1982Y] - N-terminal; Immunofluorescent staining of SH-Sy5y cells using ab76117 at 1/100 dilution.