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Home Antibody All anti-RPS6KA2 antibodies

Anti-RPS6KA2 Antibody E202

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA307066
  • Rabbit monoclonal antibody against RSK3(clone E202)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402841) , 20ug Explanation
100ul 325 3-7 Days
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IHC(1)
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Also for RPS6KA2 (NM_021135)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues surrounding threonine 353 and threonine 356 of human RSK3 was used as an immunogen.
Clone NameE202 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *IHC Suggested DilutionsICC: 1:50, IHC: 1:50-1:100, IP: 1:100, WB: 1:1,000 - 20,000,
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification IgG fraction

Reference Data

Target NameHomo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 2 (RPS6KA2), transcript variant 1
Alternative NameHU-2; MAPKAPK1C; p90-RSK3; pp90RSK3; RSK; RSK3; S6K-alpha; S6K-alpha2
Database LinkNP_066958
Entrez Gene 6196 Human
Entrez Gene 20112 Mouse
Entrez Gene 117269 Rat
FunctionRsk-3 is a member of a family of 90-kDa ribosomal protein S6 kinases, which includes Rsk-1, Rsk-2 and Rsk-3. These are broadly expressed serine/threonine protein kinases (1) that are activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2 (2). Rsk-3 is a distinct isoform of p90Rsk that translocates to the cell nucleus, phosphorylates potential nuclear targets, and may have a unique upstream activator (3). Several sites, such as Ser380, Thr359, Ser363 and Thr573, are important for its activation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB (2,4).
Related PathwayProtein KinaseDruggable Genome MAPK signaling pathwayOocyte meiosismTOR signaling pathwayLong-term potentiationNeurotrophin signaling pathwayProgesterone-mediated oocyte maturationMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

IHC Image
Immunohistochemistry (Paraffin-embedded sections) - RSK3 (phospho T353 + T356) antibody [E202]; Immunohistochemical analysis of paraffin-embedded human prostate carcinoma using TA307066 at 1/50 dilution.

 

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