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Home Antibody All anti-RPS6KA1 antibodies

Anti-RPS6KA1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306221
  • Rabbit Polyclonal RPS6K1 Antibody
100ug $325 3-7 Days
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WB(1)
IF(2)
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Also for RPS6KA1 (NM_001006665)
cDNA Clone shRNA/siRNA Primer Pair Protein Request Antibody

OriGene Data

ImmunogenRPS6K1 antibody was raised against a 16 amino acid peptide from near the carboxy-terminus of human RPS6K1.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 2.5 - 10 ug/ml, ICC: 10 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 1 (RPS6KA1), transcript variant 2
Alternative NameHU-1; MAPKAPK1A; RSK; RSK1
Database LinkNP_001006666
FunctionRibosomal protein S6 kinase 1 (RPS6K1) is the best characterized effector of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (1,2). Nutrients and growth factors stimulate a complex including TOR, raptor (regulatory associated protein of TOR), and G?L to phosphorylate RPS6K1 and the eukaryotic initiation factor 4E binding protein (4EBP1), leading to increased protein synthesis and cell growth (3). RPS6K1 is thought to desensitize tissues to insulin as mice deficient in RPS6K1 have been shown to be hypersensitive to insulin and impervious to obesity-induced insulin resistance seen in wild type obese mice (4).
Related Pathway
EGFR1 Signaling Pathway
MAPK signaling pathway

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WB Image
Western blot analysis of RPS6K1 in Jurkat cell lysate with RPS6K1 antibody at (A) 2.5, (B) 5 and (C) 10 ug/mL.
IF Image
Immunocytochemistry of RPS6K1 in Jurkat cells with RPS6K1 antibody at 10 ug/mL.
IF Image
Immunofluorescence of RP S6 Kinase in Jurkat cells with RP S6 Kinase antibody at 20 ug/mL.

 

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