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Home Antibody All anti-RPS6KA1 antibodies

Anti-RPS6KA1 PHOSPHO Antibody EP2133Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301057
  • Rabbit Monoclonal Antibody against RPS6KA1 (Clone EP2133Y) (Phospho-specific)
100ul 325 3-7 Days
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WB(1)
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Also for RPS6KA1 (NM_002953)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Threonine 573 of human RSK-1 was used as an immunogen. This antibody detects RSK-1 phosphorylated at Threonine 573.
Clone NameEP2133Y IsotypeTissue culture supernatant
Species ReactivityHuman Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:500; ICC: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt or IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 1 (RPS6KA1), transcript variant 1
Alternative NameHU-1; MAPKAPK1A; RSK; RSK1
Database LinkNP_002944
FunctionRSK 1 (p90-RSK 1) is a member of a family of 90 kDa ribosomal protein S6 kinases, which includes RSK 1, RSK 2 and RSK 3. These are broadly expressed serine/threonine protein kinases (1) activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2 (2). p90-RSK 1 is activated by MAPK in vitro and in vivo via phosphorylation (3). Active RSKs appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB (2,4).
Related Pathway
EGFR1 Signaling Pathway
MAPK signaling pathway

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WB Image
Western blot - RSK1 p90 (phospho T573) antibody [EP2133Y]; All lanes : Anti-RSK1 p90 (phospho T573) antibody [EP2133Y] at 1/500 dilution.Lane 1 : K562 cell lysate; untreated .Lane 2 : K562 cell lysate; treated with TPA.Lysates/proteins at 10 µg per lane.Secondary.goat anti-rabbit HRP conjugated, at 1/2000 dilution.Predicted band size : 83 kDa.Observed band size : 83 kDa.

 

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