Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 1 (RPS6KA1), transcript variant 1
Synonyms:
HU-1; MAPKAPK1A; RSK; RSK1
Immunogen
A phospho specific peptide corresponding to residues surrounding Threonine 573 of human RSK-1 was used as an immunogen. This antibody detects RSK-1 phosphorylated at Threonine 573.
Buffer
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
RSK 1 (p90-RSK 1) is a member of a family of 90 kDa ribosomal protein S6 kinases, which includes RSK 1, RSK 2 and RSK 3. These are broadly expressed serine/threonine protein kinases (1) activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2 (2). p90-RSK 1 is activated by MAPK in vitro and in vivo via phosphorylation (3). Active RSKs appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB (2,4).
Related Pathway
EGFR1 Signaling Pathway
MAPK signaling pathway
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.
